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Our Pipeline

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Clinical Development

Discovery

TB Alliance manages the largest pipeline of new TB drugs in history. Projects with the potential to have the greatest impact on the disease, while being cost-effective and simple to administer, are prioritized.

Lead Identification

  • Malate Synthetase InhibitorsTexas A&M University
  • PantothenamideTropIQ, Weill Cornel Medical
  • GHIT Hit-to-Lead ProgramsTakeda Pharmaceuticals, Daiichi Sankyo RD Novare
  • GHIT Hit Identification ProgramsAstellas, Fujifilm
  • Clp Lead Identification ProgramsUniversity of Illinois at Chicago, Harvard University, Center of Excellence in Translational Research (CETR)
  • PknBSchrodinger, University of Auckland
  • RNA Polymerase InhibitorsCenter of Excellence in Translational Research (CETR)
  • Whole Cell Hit-to-Lead ProgramGlaxoSmithKline

Lead Optimization

  • Anti-TB Natural ProductsEvotec
  • Intracellular Active SeriesGlaxoSmithKline
  • KasAGlaxoSmithKline
  • InhA InhibitorsGlobal Health Drug Discovery Institute
  • MmpL3 InhibitorsAbbVie, ERA4TB

Preclinical Development

  • TBAJ-587 / DiarylquinolineERA4TB
  • Preclinical TB Regimen DevelopmentJohns Hopkins University
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Our Mission

TB Alliance is a not-for-profit organization dedicated to the discovery, development and delivery of better, faster-acting and affordable tuberculosis drugs that are available to those who need them.

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News Headlines

A Persistent Shortfall in TB Research and Development Funding
Astellas and TB Alliance Enter into a New Collaborative Research Agreement to Identify Lead Compounds for the Treatment of Tuberculosis
STAND Clinical Trial Results Published

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Press Inquiries

Thomas Lynch
p | +1 646 616 8639
e | thomas.lynch@tballiance.org

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