Intracellular Active Series

Background

Mycobacterium tuberculosis (M.tb) is able to maintain infection within its human host by replicating within macrophages. M.tb does this by employing specific metabolic pathways to utilize host-derived nutrients (such as fatty acids and cholesterol) for energy production under a nutritionally-constrained environment. To identify a novel set of potential drug candidates, TB Alliance is screening libraries of small molecules against M.tb-infected human macrophages to identify novel agents which are potent against M.tb residing within macrophages.

Lead Optimization
Partners
  • GlaxoSmithKline