Intracellular Active Series


Mycobacterium tuberculosis (M.tb) is able to maintain infection within its human host by replicating within macrophages. M.tb does this by employing specific metabolic pathways to utilize host-derived nutrients (such as fatty acids and cholesterol) for energy production under a nutritionally-constrained environment. To identify a novel set of potential drug candidates, TB Alliance is screening libraries of small molecules against M.tb-infected human macrophages to identify novel agents which are potent against M.tb residing within macrophages.

Lead Optimization
  • GlaxoSmithKline