PknB

Background

The Mycobacterium tuberculosis (M.tb) genome encodes several serine/threonine protein kinases (STPK) that play important roles in mycobacterial cellular processes including cell division, cell wall synthesis, and cell metabolism. Protein kinases A and B (PknB) are involved in cell shape control and in peptidoglycan synthesis, and are essential for M.tb growth. These findings support the idea of the development of M.tb PknB inhibitors as a potential new source of anti-tuberculosis drugs.

Lead Identification
Partners
  • Schrodinger
  • University of Auckland