Research Papers

This database includes peer-reviewed publications authored or funded by TB Alliance. Use the tags on the right to filter by subject, or search for a particular author or term using the search bar.

Displaying 146 papers

Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial

11/2019 - The Lancet Respiratory Medicine

Author(s): Conor D Tweed, Rodney Dawson, Divan A Burger, Almari Conradie, Angela M Crook, Carl M Mendel, Francesca Conradie, Andreas H Diacon, Nyanda E Ntinginya, Daniel E Everitt, Frederick Haraka, Mengchun Li, Christo H van Niekerk, Alphonse Okwera

Tags: Bedaquiline (TMC-207), BPaZ, Clinical Trial Results, MDR-TB, Moxifloxacin, NC-005, PaMZ, Pretomanid/PA-824, Trial Design

Daily Dosing for Bedaquiline in Patients with Tuberculosis

10/2019 - Antimicrobial Agents and Chemotheraphy

Author(s): Salinger DH, Nedelman JR, Mendel C, Spigelman M, Hermann

Tags: Bedaquiline (TMC-207), BPaL

Estimating the impact of a novel drug regimen for treatment of tuberculosis: a modeling analysis of projected patient outcomes and epidemiological considerations

9/2019 - BMC Infectious Diseases

Author(s): Emily A. Kendall, Shelly Malhotra, Sarah Cook-Scalise, Claudia M. Denkinger, David W. Dowdy

Tags: Bedaquiline (TMC-207), Moxifloxacin, Pyrazinamide, Regimen Change

Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status

8/2019 - BMC Pulmonary Medicine

Author(s): Conor D. Tweed, Angela M. Crook, Rodney Dawson, Andreas H. Diacon, Timothy D. McHugh, Carl M. Mendel, Sarah K. Meredith, Lerato Mohapi, Michael E. Murphy, Andrew J. Nunn, Patrick P. J. Phillips, Kasha P. Singh, Melvin Spigelman, Stephen H. Gillespie

Tags: Clinical Trial Results, ReMoxTB

Population Pharmacokinetics of the Antituberculosis Agent Pretomanid

8/2019 - Antimicrobial Agents and Chemotheraphy

Author(s): David H. Salinger, Vishak Subramoney, Daniel Everitt, Jerry R. Nedelman

Tags: BPaL, Pharmacokinetics, Pretomanid/PA-824

Long-Term Effects on QT Prolongation of Pretomanid Alone and in Combinations in Patients with Tuberculosis

7/2019 - Antimicrobial Agents and Chemotheraphy

Author(s): Hanbin Li, David H. Salinger, Daniel Everitt, Mengchun Li, Angelo Del Parigi, Carl Mendel, Jerry R. Nedelman

Tags: BPaL, Pharmacodynamics, Pretomanid/PA-824

Antibacterial Activity of Coastal Plants and Marine Sponges from Kei Island Indonesia against Bacterial Fish Pathogens

7/2019 - Pharmacognosy Journal

Author(s): Andi Hamdillah, Alim Isnansetyo, Indah Istiqomah, Indun Dewi Puspita, Desy Putri Handayani, Takushi Kaneko

Tags: Drug Discovery

Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis

4/2019 - Antimicrobial Agents and Chemotheraphy

Author(s): Xu J, Li SY, Almeida DV, Tasneen R, Barnes-Boyle K, Converse PJ, Upton, Mdluli, Fotouhi, Nuermberger EL

Tags: Bedaquiline (TMC-207), BPaL, Linezolid, Moxifloxacin, Pretomanid/PA-824, Pyrazinamide

An Assessment of Global Chemistry, Manufacturing and Controls (CMC) Regulatory Requirements in Low and Middle Income Countries

11/2018 - WHO Drugs Journal

Author(s): Rajneesh Taneja, Christine Chacko, Kedar Gumaste, Subina Surendran, Arturo Olguin Pelayo, Adrienne VidalIrizarry, Diana Elkis, Arran Basra, Myrto Lee, Robert Franco

Tags: Advocacy, TB Market, TB-HIV

Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMox TB study

10/2018 - BMC Medicine (2018) 16:189

Author(s): Murphy, M.; Wills, G; Murthy, S.; Louw, C.; Bateson, A.; Hunt, R.; McHugh, T.; Nunn, A.; Meredith, S.; Mendel, C.; Spigelman, M.; Crook, A.; Gillespie, S.

Tags: ReMoxTB

Toxicity associated with tuberculosis chemotherapy in the REMoxTB study

7/2018 - BMC Infectious Diseases

Author(s): Tweed, Conor D., Crook, Angela M. Amukoye, Evans I. Dawson, Rodney Diacon, Andreas H. Hanekom, Madeline McHugh, Timothy D. Mendel, Carl M. Meredith, Sarah K. Murphy, Michael E. Murthy, Saraswathi E. Nunn, Andrew, Spigelman, M.

Tags: Clinical Trial Results, ReMoxTB

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

5/2018 - BMC Medicine

Author(s): Murthy S., Chatterjee F., Crook A., Dawson R., Mendel C., Murphy M., Murray S., Nunn A., Phillips P., Singh K., McHugh T., Gillespie S.

Tags: ReMoxTB

Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

3/2018 - BMC Medicine

Author(s): Tweed C, Mendel, C. Murray, S.,Gillespie, S., Crook, A.,et al.

Tags: Moxifloxacin, ReMoxTB

Antitubercular nitroimidazoles revisited: synthesis and activity of the authentic 3-nitro isomer of pretomanid

12/2017 - ACS Medicinal Chemistry Letters

Author(s): Andrew M. Thompson, Muriel Bonnet, Ho H. Lee, Scott G. Franzblau, Baojie Wan, George S. Wong, Christopher B. Cooper, William A. Denny

Tags: Pretomanid/PA-824

Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis

12/2017 - BMC Medicine 2017 15:207

Author(s): Patrick P. J. Phillips, Carl M. Mendel, Andrew J. Nunn, Timothy D. McHugh, Angela M. Crook, Robert Hunt, Anna Bateson and Stephen H. Gillespie

Tags: Clinical Trial Results, ReMoxTB

A comparison of liquid and solid culture for determining relapse and durable cure in phase III TB trials for new regimens

12/2017 - BMC Medicine 2017 15:207

Author(s): Patrick P. J. Phillips, Carl M. Mendel, Andrew J. Nunn, Timothy D. McHugh, Angela M. Crook, Robert Hunt, Anna Bateson and Stephen H. Gillespie

Tags: Clinical Trial Results, ReMoxTB

Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units

10/2017 - Bioorganic & Medicinal Chemistry Letters

Author(s): Peter Choi, Hamish Sutherland, Amy S.T.Tong, Adrian Blaser, Scott Franzblau, Christopher B.Cooper, Manisha U.Lotlikar, Anna M.Upton, Jerome Guillemont, Magali Motte, Laurence Queguiner, Koen Andries, Walter Van den Broeck, William A.Denny, Brian D.Palmer

Tags: Bedaquiline (TMC-207), Drug Discovery, M.tb. Biology

Tuberculosis and antimicrobial resistance - new models of research and development needed

5/2017 - Bulletin of the World Health Organization

Author(s): Brigden G, Castro JL, Ditiu L, Gray G, Hanna D, Low M, Matsoso MP, Perry G, Spigelman M, Swaminathan S, Torreele E, Wong S

Tags: MDR-TB, TB Burden, XDR-TB

The impact of HIV and antiretroviral therapy on TB risk in children: A systematic review and meta-analysis

1/2017 - Thorax Online, 23 Jan. 2017. Web. 31 Jan. 2017.

Author(s): Dodd, P. J., A. J. Prendergast, C. Beecroft, B. Kampmann, and J. A. Seddon. "The Impact of HIV and Antiretroviral Therapy on TB Risk in Children: A Systematic Review and Meta-analysis."

Tags: Childhood TB, Clinical Trial Results, TB-HIV

TB Alliance regimen development for multidrug-resistant tuberculosis

12/2016 - The International Journal of Tuberculosis and Lung Disease

Author(s): Murray, S., Mendel, C., & Spigelman, M.

Tags: Linezolid, MDR-TB, NC-005, Nix-TB, STAND/NC-006

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