The enzyme DprE1 is involved in the synthesis of arabinans which are an essential part of mycobacterial cell walls. This is a new target and these inhibitors are active against M.tb. strains resistant to known TB drugs. TBA-7371 has demonstrated in vivo efficacy and a thus far acceptable safety profile.
- A Phase 1 Study to Evaluate Safety, Tolerability, PK, and PK Interactions of TBA-7371 (clinicatrials.gov link)