Partners: Foundation for Neglected Disease Research, Bill & Melinda Gates Medical Research Institute


The enzyme DprE1 is involved in the synthesis of arabinans which are an essential part of mycobacterial cell walls. This is a new target and these inhibitors are active against M. tb strains resistant to known TB drugs. TBA-7371 has demonstrated in vivo efficacy and a thus far acceptable safety profile.

Phase 2

Trial Components