TBAJ-587 / Diarylquinoline

Chemical class: Diaryquinolines

Bedaquiline represents both a novel chemical class - diarylquinolines (DARQs) - as well as a novel M.tb-selective mechanism of action (direct inhibition of M.tb ATP synthase). This next-generation diarylquinoline project has shown potential to maintain bedaquiline’s impressive anti-TB activities while retaining additional improved properties. 

Phase 1
  • ERA4TB