TBAJ-587 / Diarylquinoline

Chemical class: Diaryquinolines
Background

Bedaquiline represents both a novel chemical class - diarylquinolines (DARQs) - as well as a novel M.tb-selective mechanism of action (direct inhibition of M.tb ATP synthase). This next-generation diarylquinoline project is designed to identify novel members of this chemical series, which maintain bedaquiline’s impressive anti-TB activities and possess improved properties. 

Preclinical Development