Regimen

SPaL (Sorfequiline [TBAJ-876] + pretomanid + linezolid)

Our Pipeline

Regimen: SPaL (Sorfequiline [TBAJ-876] + pretomanid + linezolid)

Background:

The combination of sorefequiline, pretomanid and linezolid was tested  in the NC-009 trial for its potential to shorten and improve treatment for both drug-sensitive and drug-resistant tuberculosis (TB).

The trial, which evaluated this combination, with different doses of sorfequline found that the SPaL regimen, had greater activity against TB that the standard of care, HRZE (isoniazid, rifampin, pyrazinamid, and ethambutol), indicating the potential to shorten treatment time for active TB. In addition, the SPaL regimen had a comparable safety profile to HRZE.

The SPaL regimen is expected to enter Phase 3 clinical trials in 2026.

 

Regimen Compounds

This regimen includes the following compounds:

Regimen Trials

This regimen has been evaluated in the following trials: