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Why New TB Drugs
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Why New TB Drugs
R&D
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- Annual Report
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Why New TB Drugs
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High efficacy of BPaL among patients infected with Mycobacterium tuberculosis lineage 1 in the Philippines

Publication: IJTLD Open

April 14, 2026

Exposure-QTc modeling of bedaquiline, pretomanid, and clofazimine in adults with tuberculosis

Publication: Antimicrobial Agents and Chemotherapy

March 9, 2026

Cardiodynamic evaluation of sorfequiline (TBAJ-876): results from a first-in-human study

Publication: Antimicrobial Agents and Chemotherapy

January 30, 2026

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps)

Publication: BMC Medical Education

January 24, 2026

Protocol for a phase 2, partially-blinded, randomised trial assessing the safety and efficacy of sorfequiline or bedaquiline, in combination with pretomanid and linezolid in adult participants with newly diagnosed, drug-sensitive, smear-positive pulmonary tuberculosis (NC-009)

Publication: Research Square (preprint)

December 8, 2025

Effectiveness and safety of the BPaL regimen in the Philippines

Publication: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases

December 4, 2025

In vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

Publication: bioRxiv

November 5, 2025

Children, caregivers and health workers’ perceptions and experiences of the XTEMP-R tool to improve tuberculosis treatment

Publication: PLOS Global Public Health

October 8, 2025

Population pharmacokinetics of TBAJ-587 and its mainmetabolites—Evaluation of different loading dose strategiesand early dose selection

Publication: British Journal of Clinical Pharmacology

September 24, 2025

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Treat 2,037,998 People

In the first fifteen years following BPaL’s approval, more than 2 million people treated for drug-resistant TB will be treated with BPaL/M. This means millions of people will benefit from improved treatment outcomes and experiences.

Restore 5,120,433 healthy life years

When TB doesn’t kill, it often leaves people with long periods of disability. By curing drug-resistant TB faster and more effectively, BPaL/M helps people not only survive, but recover faster, and avoid long term disabilities. That means fewer years lost to illness and more people living fully again, faster. In its first 15 years of approval, BPaL/M will result in people experiencing more than 5 million more healthy years of life.

Save an Additional 191,222 lives

BPaL/M has higher treatment success rates than previous therapies and use of these regimens is rapidly scaling up globally. In its first 15 years of approval, BPaL/M will save an additional 190,000 lives by replacing older treatments with lower success rates.

Save the world $1.29B USD

BPaL/M drastically reduces the cost of fighting drug-resistant TB for individuals, families, and governments. Hospital visits are fewer, and medicines are more affordable. As a result, in the first 15 years of approval, BPaL/M will save health systems nearly $1.3B globally. Shorter treatments also mean reduced out of pocket costs and time out of work for people receiving treatment.

The BPaL/M treatment costs less than $2 per day, however the vast majority of cost savings from implementing these new regimens is achieved through shorter and simpler treatment, reducing human and financial burden on health systems. This allows for the expansion of DR-TB care where costs and human resources have previously limited health systems’ capacities to treat DR-TB.

179,697 more people will complete treatment

Traditionally, many people receiving treatment for drug-resistant TB did not complete therapy. This was often due to the length and side effects of treatments. Those who don’t complete treatment may remain contagious and infect others, as well as suffer increased disability or death. In its first 15 years of approval, BPaL/M will lead to nearly 180,000 additional people completing treatment.

332,654 Additional Treatment Successes

People who do not complete treatment and/or follow-up are not considered to have successful treatment outcomes. Thus, additional treatment successes are about more than just “lives saved.” In its first 15 years of approval, BPaL/M will lead to more than 330,000 additional people with drug-resistant TB being successfully treated.