Research Papers

This database includes peer-reviewed publications authored or funded by TB Alliance. Use the tags on the right to filter by subject, or search for a particular author or term using the search bar.

Displaying 138 papers

Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1

5/2008 - Wang H, Ruan Z, Li JJ, et. al. Pyridine amides as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3168-72. doi: 10.1016/j.bmcl.2008.

Tags: Drug Discovery, Drug Targets, Preclinical Data

Timing of Default From Tuberculosis Treatment: A Systematic Review

5/2008 - Kruk ME, Schwalbe NR, Aguiar CA. Timing of default from tuberculosis treatment: a systematic review. Trop Med Int Health. 2008 May;13(5):703-12. doi: 10.1111/j.1365-3156.2008.02042.x.

Tags: Advocacy, Policy, Regimen Change, TB Market

The ethics of non-inferiority trials

3/2008 - Nunn AJ, Meredith SK, Spigelman MK, Ginsberg AM, Gillespie SH. The ethics of non-inferiority trials. Lancet. 2008 Mar 15;371(9616):895; author reply 896-7. doi: 10.1016/S0140-6736(08)60404-3.

Tags: Advocacy, Clinical Development, Clinical Trial Results, Editorials, Policy, Trial Design

Handbook of anti-tuberculosis agents

3/2008 - Handbook of Anti-Tuberculosis Agents. Tuberculosis (Edinb). 2008 Mar;88(2):85-6. doi: 10.1016/S1472-9792(08)70002-7.

Tags: Clinical Development, Clofazamine, Global Pipeline, HRZE, Linezolid, Moxifloxacin, Pharmacodynamics, Pharmacokinetics, Pyrazinamide, Rifapentine, Sutezolid

Advancing the science in clinical trials for new TB drugs

2/2008 - Wells WA, Brooks A. Adoption of new health products in low and middle income settings: how product development partnerships can support country decision making. Health Res Policy Syst. 2011 Mar 31;9:15. doi: 10.1186/1478-4505-9-15.

Tags: Biomarkers, Clinical Development, Editorials, Moxifloxacin, Trial Design

New tuberculosis therapeutics: a growing pipeline

8/2007 - Spigelman MK New tuberculosis therapeutics: a growing pipeline. J Infect Dis. 2007 Aug 15;196 Suppl 1:S28-34. http://jid.oxfordjournals.org/content/196/Supplement_1/S28.long. Accessed March 7, 2016

Tags: Clinical Development, Editorials, Global Pipeline, MDR-TB, Moxifloxacin, Pretomanid/PA-824, Rifapentine, TB-HIV

Turning the tide on tuberculosis: a combined effort

7/2007 - Spigleman M. Turning the tide on tuberculosis: a combined effort. SciDevNet. 2007 4 Jul. http://www.scidev.net/global/health/opinion/turning-the-tide-on-tuberculosis-a-combined-effor.html. Accessed March 11, 2016

Mycobacterium tuberculosis DNA gyrase as a target for drug discovery

6/2007 - Mdluli K, Ma Z. Mycobacterium tuberculosis DNA gyrase as a target for drug discovery. Infect Disord Drug Targets. 2007 Jun;7(2):159-68. http://www.ingentaconnect.com/content/ben/iddt/2007/00000007/00000002/art00008?token=00521b85a26b1174e1f7b76504c48662a2

Tags: Drug Discovery, Drug Targets, M.tb. Biology, MDR-TB, Preclinical Data

Challenges associated with current and future TB treatment

6/2007 - Laurenzi M, Ginsberg AM, Spigelman M. Challenges associated with current and future TB treatment. Infect Disord Drug Targets. 2007 Jun;7(2):105-19. http://www.ingentaconnect.com/content/ben/iddt/2007/00000007/00000002/art00004?token=004e1567d370e7e442f206

Author(s): Laurenzi, M., A. Ginsberg, and M. Spigelman

Tags: Advocacy, Clinical Development, Editorials, Global Pipeline, Trial Design

Planning to improve global health: the next decade of tuberculosis control

5/2007 - Dermot Maher, Chris Dye, Katherine Floyd, et. al. Planning to improve global health: the next decade of tuberculosis control. Bull World Health Organ. 2007 May; 85(5): 341–347. doi: 10.2471/06.037820

Tags: Advocacy, Editorials, MDR-TB, Policy, TB Burden, TB-HIV

Challenges in tuberculosis drug research and development

3/2007 - Ginsberg AM, Spigelman M. Challenges in tuberculosis drug research and development. Nat Med. 2007 Mar;13(3):290-4. http://www.nature.com/nm/journal/v13/n3/full/nm0307-290.html. Accessed March 7, 2016

Tags: Clinical Development, Editorials, Global Pipeline, Trial Design

Antimycobacterium Agents

1/2007 - Ma Z, Ginsberg A, Spigelman M. Antimycobacterium Agents. Elsevier, Philadelphia, PA. 2007 Jan; 700-4, 719-20, 26.

Tags: Clinical Development, Drug Discovery, Drug Targets, Global Pipeline, M.tb. Biology, MDR-TB, Moxifloxacin, Preclinical Models, Pretomanid/PA-824, Pyrazinamide, Rifapentine, TB-HIV, Trial Design

Novel targets for tuberculosis drug discovery

10/2006 - Mdluli K, Spigelman M. Novel targets for tuberculosis drug discovery. Curr Opin Pharmacol. 2006 Oct;6(5):459-67. http://www.sciencedirect.com/science/article/pii/S1471489206001354. Accessed March 7, 2016

Tags: Drug Discovery, Drug Targets, M.tb. Biology

Tuberculosis drug development pipeline: progress and hope

3/2006 - Spigelman M, Gillespie S. Tuberculosis drug development pipeline: progress and hope. Lancet. 2006 Mar 18;367(9514):945-7. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(06)68388-8/abstract. Accessed March 7, 2016

Tags: Advocacy, Clinical Development, Drug Discovery, Editorials, Global Pipeline

Opportunities for overcoming tuberculosis: new treatment regimens

1/2006 - Freire MC. Opportunities for overcoming tuberculosis: new treatment regimens. World Hosp Health Serv. 2006;42(1):34-7. http://www.ncbi.nlm.nih.gov/pubmed/16669375. Accessed March 7, 2016

Tags: Advocacy, Clinical Development, Editorials, Global Pipeline, Policy, Trial Design

New drugs for tuberculosis: current status and future prospects

6/2005 - O'Brien RJ, Spigelman M. New drugs for tuberculosis: current status and future prospects. Clin Chest Med. 2005 Jun;26(2):327-40, vii. http://www.sciencedirect.com/science/article/pii/S0272523105000158. Accessed March 7, 2016

Tags: Clinical Development, Drug Discovery, Editorials, Global Pipeline, Moxifloxacin, Pretomanid/PA-824, Rifapentine

Mycobacterium tuberculosis: new tricks for an old bug

8/2004 - Spigelman M, Ma Z. Mycobacterium tuberculosis: new tricks for an old bug. Expert Rev Anti Infect Ther. 2004 Aug;2(4):467-9.https://www.researchgate.net/publication/8234528_Mycobacterium_tuberculosis_New_tricks_for_an_old_bug. Accessed March 7, 2016

Tags: Advocacy, Drug Discovery, Drug Targets, Editorials, Global Pipeline, Pharmacokinetics

Joining forces to develop weapons against TB: together we must.

1/2002 - Freire M, Roscigno G. Joining forces to develop weapons against TB: together we must. Bull World Health Organ. 2002;80(6):429. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567524/pdf/12131997.pdf. Accessed March 7, 2016

Tags: Advocacy, Editorials, MDR-TB, Moxifloxacin, Pretomanid/PA-824, TB-HIV

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