]

Pantothenamide

Background

Pantothenamides act both as bifunctional competitive inhibitors and replacement substrates of de novo CoA (coenzyme A) biosynthesis and acyl-CoA metabolism in M. tb, respectively. The original hits came from a malaria project where some of the hits demonstrated antibacterial activity against M. tb.

Lead Identification
Partners
  • TropIQ
  • Weill Cornel Medical