]

Clp Lead Identification Programs

Background

The Clp complex is an essential proteosome function required to remove damaged or misfolded proteins from M. tb. Inhibition may result in enhanced bactericidal effects in combination with a variety of current M. tb antibiotics. Current leads are based on well-established substrate mimetics.

Lead Identification
Partners
  • University of Illinois at Chicago
  • Texas A&M University
  • Harvard University
  • Center of Excellence in Translational Research (CETR)