TB Alliance Calls on WHO to Add TB to List of Bacteria in Critical Need of Antibiotics

First-ever list of antibiotic-resistant "priority pathogens" excludes mycobacterium tuberculosis

February 28, 2017

TB Alliance and the broader TB community urge that the World Health Organization (WHO) add Mycobacterium tuberculosis to the critical group within the list of drug-resistant bacteria identified as urgent priorities for research and development.

“The absence of TB from this list is shocking,” said Mel Spigelman, President and C.E.O. of TB Alliance. “The effort to develop new drugs to cure TB has always been chronically underfunded despite the disease’s impact.” TB is the world's deadliest infectious disease, killing 1.8 million people each year.

TB patients urgently need new and better antibiotics. Treatment for drug-resistant TB is long, toxic, complicated, and expensive. It can consist of more than two years of a dozen or more pills per day, along with six months of daily injections. And for those unfortunate enough to have extensively resistant TB, even if they take every one of those 20,000 toxic pills and hundreds of injections, they will still have less than a one in three chance of survival. Put simply, TB has evolved at a speed that outpaces our underfunded research community.

This year alone, approximately half a million people will develop drug-resistant TB. Multidrug-resistant TB (MDR-TB) is caused by TB bacteria that is resistant to at least isoniazid and rifampin, the two most potent TB drugs. Less than 20 percent of people with MDR-TB receive treatment; of that small fraction, about half are cured. To place the drug resistant TB situation in perspective, patients with Ebola, for whom there is no available drug therapy, have the same chances of survival that patients with drug-resistant TB patients have, accessing today’s available medicines. MDR-TB is also the most contagious of all the pathogens noted on the WHO’s list, spreading readily from person to person, and is especially dangerous to children, people with HIV, and other vulnerable populations.

About 29 percent of deaths caused by antimicrobial infections are due to drug-resistant TB, according to recent figures published by the AMR Review. The UK All Party Parliamentary Group on Global Tuberculosis estimated that MDR-TB could cost the world $16.7 trillion by 2050. Last year's high-level meeting on AMR at the UN General Assembly affirmed that TB is critical to the antimicrobial resistance (AMR) agenda.

New tools, including vaccines, diagnostics, and treatments, cannot be developed without adequate resources, and the global TB community faces significant underfunding. The WHO’s 2011-2015 Global Plan to Stop TB saw a five-year funding deficit of $2.4 billion in drug R&D, and 2015 saw the biggest decline in R&D funding for TB in over a decade. Even efforts to treat and prevent the disease are underfunded by almost $2 billion, according to the WHO.

Drug-resistant TB is an urgent and critical priority. Without more attention and new antibiotics, the disease will continue to wreak havoc among the world’s poorest communities. It is not enough to say that TB is being addressed by other health programs; drug-resistant TB is the biggest global threat in AMR and it must be recognized as such, especially by the WHO. The absence of TB from the WHO list is an irresponsible public health statement, sending the wrong message about global health  priorities.

WHO did issue a follow-up release affirming the critical need for R&D of new antibiotics to tackle drug-resistant tuberculosis. This effort, however, should not be separate from efforts to address other drug-resistant pathogens. Every global effort to address the burgeoning AMR emergency must include TB, and the WHO should be taking a leadership role in this effort, starting with the inclusion of TB on the new WHO list of priority pathogens.

Update as of March 2, 2017: Read TB Alliance President and C.E.O Mel Spigelman's letter to WHO Director-General Margaret Chan expressing these concerns


About TB Alliance (Global Alliance for TB Drug Development)

TB Alliance is a not-for-profit organization dedicated to finding faster-acting and affordable drug regimens to fight tuberculosis (TB). Through innovative science and with partners around the globe, we aim to ensure equitable access to faster, better TB cures that will advance global health and prosperity. TB Alliance operates with support from Australia’s Department of Foreign Affairs and Trade, Bill & Melinda Gates Foundation, Germany’s Federal Ministry of Education and Research, Global Health Innovative Technology Fund, Irish Aid, Indonesia Health Fund, National Institute of Allergy and Infectious Disease, Netherlands Ministry of Foreign Affairs, UNITAID, United Kingdom Department for International Development, United States Agency for International Development, and the United States Food and Drug Administration.