Department: Discovery

Director, Preclinical Drug Evaluation

Summary:

The Director of Preclinical Drug Evaluation will be a key member of the TB Alliance’s Research and Development team and responsible for managing programs in preclinical development. In addition, she/he will play a supporting role in advancing discovery and clinical programs.  This position will report directly to the Chief Scientific Officer.

Position description:

The Director will be responsible for helping to implement the research and pre-clinical development strategy of the TB Alliance.  As a key member of the TB Alliance’s Research and Development team, the Director will:

  • Advise and support the Head of Discovery in overseeing the TB Alliance’s discovery and preclinical projects, ensuring timely and quality technical performance. Help develop and ensure cost-efficient methods for going from leads to drug candidates, and ultimately the filing of INDs
  • Provide scientific, technical and leadership on ADME, DMPK and toxicology for all projects in the portfolio from preclinical to clinical development.
  • Lead or co-Lead a portion of the TB Alliance preclinical portfolio
  • Be involved in the identification, evaluation and selection of potential portfolio projects and appropriate compounds and product candidates for TB drug development
  • Marshal appropriate cutting-edge technologies to drive forward existing and future programs.
  • Collaborate in a productive manner within the TB Alliance team to help drive and maximize the TB Alliance’s research and development activities
  • Represent the TB Alliance externally in scientific, financial and business development communities and in meetings with regulatory bodies
  • Report progress towards research milestones to the Head of Research, the Research and Development team, the Scientific Advisory Committee and TB Alliance management.
  • Evaluate the progress of portfolio projects to ensure that TB Alliance resources are being put to best use and that the projects will meet all critical success factors, and prepare materials for interim and formal project reviews
  • Help manage and build the TB Alliance’s research capabilities, ensuring a culture that is capable of attracting and retaining the best talents
  • Stay current on developments in TB biology and R&D in industry and academia
  • Ensure timely publication of research papers and maintain association with scientific and professional organizations to enhance the TB Alliance’s prestige
  • Responsible for compliance with applicable GxP regulations in performing the functions of the job.
  • Attendance at annual GxP or other applicable regulatory trainings provided by TB Alliance.

 

Ideal candidates will have:

  • A Ph.D. in pharmacology/toxicology or related disciplines from a well-respected academic institution is required.
  • 5+ Years of working experience in a research leadership capacity within a pharmaceutical/biotechnology company.
  • Experience in preclinical development with a thorough understanding of the requirements and processes needed to take a potential drug candidate from discovery into clinical trials.
  • A successful track record in delivering drug candidates for development, preferably in the infectious disease area.
  • A broad knowledge base in drug discovery and clinical development and experience with both discovery and development programs.
  • Broad exposure to product development with an understanding of the complex interface between research and clinical development.
  • Familiarity with regulatory guidelines governing the chemical, pharmacological, pharmacokinetic and toxicological aspects of a successful IND.
  • An international network of contacts, recognition as a leader in the scientific community with a strong reputation in the life science arena.
  • Ability to interact in a positive manner with governments, funding agencies and the highest level of research management in pharmaceutical/ biotech companies.
  • Proven management and leadership skills with the ability to work in a team-oriented environment.
  • Ability to present well in an international setting and have the interest and ability to become an expert in TB.
  • Strong communication, presentation and interpersonal skills with the ability to build effective working alliance.
  • A sense of purpose and dedication to the mission of the TB Alliance and its not-for-profit focus.

Location:

New York, NY

Organizational Information:

TB Alliance is a not-for-profit organization dedicated to the discovery and development of better, faster, affordable tuberculosis drugs that are available to those who need them.Through innovative science and with partners around the globe, we lead a global effort to ensure development of and equitable access to faster, better tuberculosis cures that will advance global health and prosperity.

With an annual operating budget of approximately $60 million, the TB Alliance leads the advancement of the most comprehensive R&D portfolio of TB drug candidates in history. Additionally, the TB Alliance drives efforts to ensure regulatory approval, country adoption of new regimens, and widespread availability of new drug regimens to patients. For more information, please access the website: www.tballiance.org.

Our Pipeline

TB Alliance manages the largest pipeline of new TB drugs in history.

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