Progress in the Pipeline
A number of advances in the discovery stages of the drug development pipeline took place over the course of 2016. Thanks to ongoing collaboration among our research partners, more drug candidates advanced to IND-enabling studies in 2016 than in the previous five years combined.
This includes two new compounds that advanced into preclinical development: TBAJ-587 (a diarylquinoline), which was discovered in collaboration with Janssen and Auckland Cancer Society Research Center, and TBI-223 (an oxazolidinone), which was discovered with the Institute of Materia Medica. In partnership with Eli Lilly, TB Alliance has also progressed the TBA-7371 compound. All three of these compounds are active against drug resistant strains of TB, and TBA-7371, which inhibits part of TB's cell wall biosynthesis, has a completely novel mode of action against TB.
Additional work on other compounds continued. Collaborations with pharmaceutical partners Sanofi and GlaxoSmithKline are poised to deliver more compounds into the preclinical development phase in 2017.
Over the past year, based on success in the discovery pipeline, TB Alliance expanded its partnership with the Global Health Innovative Technology Fund, an international non-profit organization based in Japan that fosters industry collaboration in global health. A number of
hits or promising compounds, were identified as a result of natural-product based screens being carried out in collaboration with OP Bio, Daiichi-Sankyo Novare, HyphaGenesis, and Chugai. Funding from the Indonesia Health Fund has also permitted advancing research into natural products in Indonesia.
How We Target TB
TB Alliance is pursuing five major approaches to targeting TB cells with drugs. These explanatory graphics provide an overview of how TB drugs work at a cellular level. The novel compounds advanced into preclinical development in 2016 target cell wall disruption, electron transport chain, and protein synthesis.